ANCA Screening
ANCA screening is important when autoimmune vasculitis is suspected. Early identification of ANCA positivity enables timely specialist referral and treatment.
Doctor's Assessment Included
ANCA Screening: what this test measures
This screening test detects ANCA antibodies and classifies them as c-ANCA (cytoplasmic, typically anti-PR3) or p-ANCA (perinuclear, typically anti-MPO). The pattern helps differentiate between vasculitis types.
ANCA Screening: why this value matters
ANCA-associated vasculitis can affect kidneys, lungs, and other organs with potentially life-threatening consequences. Early detection enables prompt immunosuppressive treatment.
ANCA Screening: how the blood test works
- Referral
- No GP referral needed. After the order we arrange the referral through ZorgDomein, within one business day; orders after 17:00 or at the weekend start on the next business day. ZorgDomein emails a barcode, and that barcode is what the draw site needs.
- The draw
- A blood draw from a vein in the arm, at a partner laboratory's draw site. No home kit, no finger prick.
- Which test
- on its own €65,-
- Where
- 650+ draw sites run by independent laboratories across the Netherlands. Draw sites
ANCA Screening: when is testing worthwhile?
Testing could be indicated for suspected vasculitis: unexplained kidney disease with active sediment, pulmonary-renal syndrome, recurrent sinusitis with systemic symptoms, or unexplained multi-organ inflammation.
ANCA Screening: symptoms of a high or low value
Low Levels
A negative ANCA result makes ANCA-associated vasculitis less likely but does not completely exclude it, particularly in limited disease forms.
High Levels
A positive ANCA may be associated with vasculitis symptoms including fatigue, weight loss, fever, joint pain, skin lesions, kidney dysfunction, respiratory symptoms, and nerve damage.
ANCA Screening: lifestyle and this value
If ANCA is positive with symptoms, urgent referral to a specialist is important as vasculitis can progress rapidly. Treatment typically involves immunosuppressive therapy. Regular monitoring of kidney function and blood counts is essential during treatment.
ANCA Screening: frequently asked questions
What is ANCA-associated vasculitis?
A group of autoimmune conditions causing inflammation of small blood vessels. GPA, MPA, and EGPA are the main types, each with distinct features.
What is the difference between c-ANCA and p-ANCA?
c-ANCA (anti-PR3) is most commonly associated with GPA. p-ANCA (anti-MPO) is more common in MPA. The pattern helps guide diagnosis.
Can vasculitis be treated?
Yes. Modern immunosuppressive therapy has dramatically improved outcomes. Most patients achieve remission, though long-term monitoring for relapse is important.
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Doctor's Assessment Included
Every result includes a professional assessment from a BIG-registered doctor. For treatment decisions, discuss your results with your GP.
ANCA Screening
€65,-