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Doctor's Assessment Included

Every result includes a professional assessment from a BIG-registered doctor. For treatment decisions, discuss your results with your GP.

Autoimmune

ANCA Screening

ANCA screening is important when autoimmune vasculitis is suspected. Early identification of ANCA positivity enables timely specialist referral and treatment.

What It Measures

This screening test detects ANCA antibodies and classifies them as c-ANCA (cytoplasmic, typically anti-PR3) or p-ANCA (perinuclear, typically anti-MPO). The pattern helps differentiate between vasculitis types.

Why It Matters

ANCA-associated vasculitis can affect kidneys, lungs, and other organs with potentially life-threatening consequences. Early detection enables prompt immunosuppressive treatment.

When to Test

Testing can be indicated for suspected vasculitis: unexplained kidney disease with active sediment, pulmonary-renal syndrome, recurrent sinusitis with systemic symptoms, or unexplained multi-organ inflammation.

Symptoms

Low Levels

A negative ANCA result makes ANCA-associated vasculitis less likely but does not completely exclude it, particularly in limited disease forms.

High Levels

A positive ANCA may be associated with vasculitis symptoms including fatigue, weight loss, fever, joint pain, skin lesions, kidney dysfunction, respiratory symptoms, and nerve damage.

Lifestyle Tips

If ANCA is positive with symptoms, urgent referral to a specialist is important as vasculitis can progress rapidly. Treatment typically involves immunosuppressive therapy. Regular monitoring of kidney function and blood counts is essential during treatment.

Frequently Asked Questions

What is ANCA-associated vasculitis?
A group of autoimmune conditions causing inflammation of small blood vessels. GPA, MPA, and EGPA are the main types, each with distinct features.
What is the difference between c-ANCA and p-ANCA?
c-ANCA (anti-PR3) is most commonly associated with GPA. p-ANCA (anti-MPO) is more common in MPA. The pattern helps guide diagnosis.
Can vasculitis be treated?
Yes. Modern immunosuppressive therapy has dramatically improved outcomes. Most patients achieve remission, though long-term monitoring for relapse is important.