Anti-Cardiolipin IgG
Anti-cardiolipin IgG is a key marker for antiphospholipid syndrome. Including it in an autoimmune screen helps identify this treatable cause of thrombosis.
Doctor's Assessment Included
Anti-Cardiolipin IgG: what this test measures
This test quantifies IgG antibodies directed against cardiolipin. Results are reported in GPL units. Medium-to-high positive titres are more clinically significant than low positive results.
Anti-Cardiolipin IgG: why this value matters
Anti-cardiolipin IgG is one of three criteria antibodies for APS diagnosis. Persistent positivity combined with thrombosis or pregnancy morbidity confirms APS. IgG is more strongly associated with clinical events than IgM.
Anti-Cardiolipin IgG: how the blood test works
- Referral
- No GP referral needed. After the order we arrange the referral through ZorgDomein, within one business day; orders after 17:00 or at the weekend start on the next business day. ZorgDomein emails a barcode, and that barcode is what the draw site needs.
- The draw
- A blood draw from a vein in the arm, at a partner laboratory's draw site. No home kit, no finger prick.
- Which test
- on its own €65,-
- Where
- 650+ draw sites run by independent laboratories across the Netherlands. Draw sites
Anti-Cardiolipin IgG: when is testing worthwhile?
Testing could be indicated for unexplained thrombosis, recurrent pregnancy loss, unexplained prolonged aPTT, or suspected APS. Confirm positive results at least 12 weeks later.
Anti-Cardiolipin IgG: symptoms of a high or low value
Low Levels
A negative result is normal and does not require follow-up in the absence of clinical suspicion.
High Levels
Elevated anti-cardiolipin IgG may be associated with venous and arterial thrombosis, recurrent pregnancy loss, thrombocytopenia, and livedo reticularis.
Anti-Cardiolipin IgG: lifestyle and this value
If persistently positive, discuss long-term anticoagulation with your specialist. Reduce modifiable thrombosis risk factors. Avoid oestrogen-containing contraception. Plan pregnancies with specialist guidance.
Anti-Cardiolipin IgG: frequently asked questions
What is antiphospholipid syndrome?
An autoimmune condition where antibodies against phospholipids cause increased blood clotting and pregnancy complications. Diagnosis requires persistent antibodies plus a clinical event.
Why test both IgG and IgM?
IgG is more strongly linked to thrombosis. IgM may be transiently positive with infections. Testing both provides a complete picture of antiphospholipid antibody status.
Can anti-cardiolipin be transiently positive?
Yes. Infections can cause transient positivity. APS diagnosis requires confirmation at 12+ weeks to exclude transient causes.
Medical reviewer
Medical standards
Dr. Naimi oversees the medical standards behind our content and assessments.
Medical policy
Welzijn en Sport Official BIG registration BIG 49928676701 Opens in a new tab
Doctor's Assessment Included
Every result includes a professional assessment from a BIG-registered doctor. For treatment decisions, discuss your results with your GP.
Anti-Cardiolipin IgG
€65,-