Anti-CCP is the gold standard serological test for rheumatoid arthritis. Early detection through proactive screening enables treatment before irreversible joint damage occurs.
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This test detects antibodies against cyclic citrullinated peptides. Citrullination is a protein modification that occurs in inflamed joints, and the immune response to these modified proteins is characteristic of RA.
Anti-CCP has approximately 95% specificity for RA, making it the most specific serological marker. Its presence predicts more severe, erosive disease, enabling early aggressive treatment to prevent joint damage.
Testing could be indicated for suspected RA: symmetric joint pain and swelling (especially small joints of hands and feet), morning stiffness lasting over 30 minutes, or positive rheumatoid factor needing confirmation.
A negative anti-CCP does not exclude RA. Approximately 20-30% of RA patients are seronegative (negative for both RF and anti-CCP).
A positive anti-CCP in the context of joint symptoms strongly supports RA diagnosis. It predicts more aggressive disease with joint erosions and may be present years before clinical symptoms develop.
If anti-CCP positive with symptoms, early rheumatology referral is crucial. Modern RA treatment aims to achieve remission through early, aggressive therapy. Regular exercise, joint protection techniques, and smoking cessation are important.
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Every result includes a professional assessment from a BIG-registered doctor. For treatment decisions, discuss your results with your GP.
Anti-CCP
€52,-
