Doctor's Assessment Included
Every result includes a professional assessment from a BIG-registered doctor. For treatment decisions, discuss your results with your GP.
ENA (Extractable Nuclear Antigens)
ENA testing provides specific autoimmune disease classification when ANA is positive. Each antibody points to a different condition, enabling targeted evaluation.
What It Measures
This panel measures antibodies against multiple extractable nuclear antigens. The specific antibody profile helps differentiate between SLE, Sjogren syndrome, scleroderma, mixed connective tissue disease, and polymyositis.
Why It Matters
ENA profiling is essential for accurate autoimmune disease classification. Anti-Ro is associated with neonatal lupus and congenital heart block risk in pregnancy. Anti-Sm is highly specific for SLE.
When to Test
Testing could be indicated when ANA is positive and specific autoimmune disease classification is needed, or when clinical features suggest a specific connective tissue disease.
Symptoms
Low Levels
High Levels
Lifestyle Tips
If specific ENA antibodies are positive, consult a rheumatologist for targeted evaluation. Management depends on the specific antibody and associated condition. Sun protection is important for lupus-associated antibodies.