RNA Polymerase III
RNA Polymerase III antibodies are specific autoantibodies associated with systemic sclerosis. Testing for these antibodies provides comprehensive insight into autoimmune activity and can support early identification of connective tissue disorders.
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RNA Polymerase III: what this test measures
This test detects the presence and level of anti-RNA Polymerase III antibodies in your blood. These antibodies are a specific marker for a subtype of systemic sclerosis and can help guide clinical assessment.
RNA Polymerase III: why this value matters
The presence of RNA Polymerase III antibodies may indicate systemic sclerosis with diffuse skin involvement and can be associated with an increased risk of renal crisis. Early detection can support timely monitoring and management of potential complications.
RNA Polymerase III: how the blood test works
- Referral
- No GP referral needed. After the order we arrange the referral through ZorgDomein, within one business day; orders after 17:00 or at the weekend start on the next business day. ZorgDomein emails a barcode, and that barcode is what the draw site needs.
- The draw
- A blood draw from a vein in the arm, at a partner laboratory's draw site. No home kit, no finger prick.
- Which test
- on its own €75,-
- Where
- 650+ draw sites run by independent laboratories across the Netherlands. Draw sites
RNA Polymerase III: when is testing worthwhile?
Testing may be recommended when symptoms of systemic sclerosis are present, such as skin thickening, Raynaud's phenomenon, or difficulty swallowing. It is also used as part of a comprehensive autoimmune antibody panel. Consult a healthcare professional for interpretation of results.
RNA Polymerase III: symptoms of a high or low value
Low Levels
Absence of RNA Polymerase III antibodies is not typically associated with specific symptoms and is generally considered a standard finding
High Levels
Rapid skin thickening, Raynaud's phenomenon (colour changes in fingers and toes), difficulty swallowing, shortness of breath, joint stiffness, kidney-related symptoms such as elevated blood pressure
RNA Polymerase III: lifestyle and this value
Keeping hands and feet warm can help manage Raynaud's symptoms. Gentle stretching and physical therapy may support skin and joint flexibility. Avoiding smoking is strongly recommended, as it can worsen circulation problems. Regular medical follow-up is important for monitoring disease progression.
RNA Polymerase III: frequently asked questions
What is systemic sclerosis?
Systemic sclerosis (scleroderma) is a chronic autoimmune condition that causes thickening and hardening of the skin and can affect internal organs. RNA Polymerase III antibodies are associated with a specific subtype of this condition.
Does a positive result confirm systemic sclerosis?
A positive result is strongly associated with systemic sclerosis but must be interpreted alongside clinical symptoms, physical examination, and other diagnostic tests by a healthcare professional.
How common are RNA Polymerase III antibodies?
These antibodies are found in approximately 10 to 25 percent of patients with systemic sclerosis. They are relatively specific to this condition, making them a useful diagnostic marker.
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Doctor's Assessment Included
Every result includes a professional assessment from a BIG-registered doctor. For treatment decisions, discuss your results with your GP.
RNA Polymerase III
€75,-