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Doctor's Assessment Included

Every result includes a professional assessment from a BIG-registered doctor. For treatment decisions, discuss your results with your GP.

Autoimmune

RNA Polymerase III

RNA Polymerase III antibodies are specific autoantibodies associated with systemic sclerosis. Testing for these antibodies provides comprehensive insight into autoimmune activity and can support early identification of connective tissue disorders.

What It Measures

This test detects the presence and level of anti-RNA Polymerase III antibodies in your blood. These antibodies are a specific marker for a subtype of systemic sclerosis and can help guide clinical assessment.

Why It Matters

The presence of RNA Polymerase III antibodies may indicate systemic sclerosis with diffuse skin involvement and can be associated with an increased risk of renal crisis. Early detection can support timely monitoring and management of potential complications.

When to Test

Testing may be recommended when symptoms of systemic sclerosis are present, such as skin thickening, Raynaud's phenomenon, or difficulty swallowing. It is also used as part of a comprehensive autoimmune antibody panel. Consult a healthcare professional for interpretation of results.

Symptoms

Low Levels

Absence of RNA Polymerase III antibodies is not typically associated with specific symptoms and is generally considered a standard finding

High Levels

Rapid skin thickening, Raynaud's phenomenon (colour changes in fingers and toes), difficulty swallowing, shortness of breath, joint stiffness, kidney-related symptoms such as elevated blood pressure

Lifestyle Tips

Keeping hands and feet warm can help manage Raynaud's symptoms. Gentle stretching and physical therapy may support skin and joint flexibility. Avoiding smoking is strongly recommended, as it can worsen circulation problems. Regular medical follow-up is important for monitoring disease progression.

Frequently Asked Questions

What is systemic sclerosis?
Systemic sclerosis (scleroderma) is a chronic autoimmune condition that causes thickening and hardening of the skin and can affect internal organs. RNA Polymerase III antibodies are associated with a specific subtype of this condition.
Does a positive result confirm systemic sclerosis?
A positive result is strongly associated with systemic sclerosis but must be interpreted alongside clinical symptoms, physical examination, and other diagnostic tests by a healthcare professional.
How common are RNA Polymerase III antibodies?
These antibodies are found in approximately 10 to 25 percent of patients with systemic sclerosis. They are relatively specific to this condition, making them a useful diagnostic marker.