Allergy & Intolerance

Tryptase Test

Tryptase testing provides a baseline measurement of mast cell activity, enabling faster diagnosis during any future severe allergic reaction.

Doctor's Assessment Included

Tryptase: what this test measures

This test measures total tryptase concentration. Acute tryptase peaks 1-2 hours after anaphylaxis. Baseline tryptase reflects overall mast cell burden.

Tryptase: why this value matters

Elevated baseline tryptase may indicate mastocytosis. Acute elevation supports anaphylaxis diagnosis. Knowing your baseline enables comparison during future allergic emergencies.

Tryptase: how the blood test works

Referral: No GP referral needed. After the order we arrange the referral through ZorgDomein, within one business day; orders after 17:00 or at the weekend start on the next business day. ZorgDomein emails a barcode, and that barcode is what the draw site needs.
The draw: A blood draw from a vein in the arm, at a partner laboratory's draw site. No home kit, no finger prick.
Which test: on its own €91,-
Where: 650+ draw sites run by independent laboratories across the Netherlands. Draw sites

Tryptase: when is testing worthwhile?

Baseline tryptase is recommended for individuals with severe allergic reaction history, suspected mastocytosis, or unexplained anaphylaxis. During events, draw blood 1-2 hours after symptom onset.

Tryptase: symptoms of a high or low value

Low Levels

Low tryptase levels are normal and suggest low mast cell burden. Mast cell disorders are unlikely.

High Levels

Elevated baseline tryptase may indicate mastocytosis or hereditary alpha-tryptasaemia. Acutely elevated tryptase suggests anaphylaxis. Symptoms may include severe flushing, low blood pressure, and breathing difficulty.

Tryptase: lifestyle and this value

If elevated baseline tryptase is found, work with an allergist to determine the cause. Carry emergency medication if prescribed and wear medical identification. Avoid known triggers.

Tryptase: frequently asked questions

Why should I know my baseline tryptase?

It allows comparison during suspected allergic emergencies. A significant rise above baseline strongly supports anaphylaxis diagnosis.

What is mastocytosis?

A condition where abnormal mast cells accumulate in tissues. It can cause flushing, itching, and severe reactions. Elevated baseline tryptase is a diagnostic criterion.

When should tryptase be drawn after a reaction?

Ideally 1-2 hours after symptom onset. A second sample at 24 hours provides your baseline for comparison.

Tests with related values

These panels measure values from the same category as this marker.

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