Graves Disease

Graves' disease is an autoimmune condition in which antibodies stimulate the thyroid to produce excess hormones. Standard thyroid tests (TSH, Free T3, Free T4) can show the effect on hormone levels, but TSH receptor antibodies can help distinguish Graves' disease from other causes of an overactive thyroid. This panel combines both types of markers for a more targeted assessment.

This test may be relevant for:

• People who have been told they have an overactive thyroid and want to investigate the cause
• Those with a family history of Graves' disease or autoimmune thyroid conditions
• Anyone experiencing symptoms such as rapid heart rate, unexplained weight loss, tremor, or anxiety alongside abnormal thyroid results
• People who have been diagnosed with Graves' disease and want to monitor their antibody levels

This panel includes four markers:

• TSH (Thyroid-Stimulating Hormone): typically suppressed in Graves' disease because the thyroid is being stimulated by antibodies instead
• Free T4 (Thyroxine): the main thyroid hormone; often elevated in an overactive thyroid
• Free T3 (Triiodothyronine): the more active thyroid hormone; may also be elevated
• TSH Receptor Antibodies (TRAb): antibodies that bind to TSH receptors on the thyroid, stimulating it to produce excess hormones. Their presence is a characteristic marker of Graves' disease.

A suppressed TSH combined with elevated Free T4 and/or Free T3 suggests an overactive thyroid. The presence of TSH receptor antibodies can help indicate whether Graves' disease may be the underlying cause, as opposed to other conditions such as toxic nodular goitre or thyroiditis.

It is worth noting that antibody levels can fluctuate over time, and a single measurement provides a snapshot. A healthcare provider can help interpret the full pattern.

This test uses a blood sample collected at a certified sample point (afnamepunt). With over 750 partner locations across the Netherlands, you can choose a convenient location. A trained phlebotomist performs the blood draw, and results are typically available within a few working days.

This test may be useful when:

• You have been found to have an overactive thyroid and want to investigate the cause
• You have symptoms of hyperthyroidism and want to check for autoimmune involvement
• You have a known diagnosis of Graves' disease and want to monitor antibody levels
• There is autoimmune thyroid disease in your family and you want to check your markers

Each marker is shown with your value and the reference range. Positive TSH receptor antibodies in combination with suppressed TSH and elevated thyroid hormones form a pattern consistent with Graves' disease. However, the results should be interpreted by a healthcare provider in the context of your symptoms and medical history.

Your report includes explanations for each marker. We recommend discussing the results with a healthcare provider, especially if antibody levels are elevated or thyroid values are outside the expected range.

No specific preparation is needed for this test. If you are taking thyroid medication, follow your usual routine unless your healthcare provider advises otherwise. Inform your healthcare provider about any medications you take, as some can affect thyroid hormone levels.

Your results are typically available within a few working days. The report includes your values with reference ranges and clear explanations. If TSH receptor antibodies are detected or thyroid values fall outside the expected range, this is highlighted. We recommend discussing the results with a healthcare provider, who can advise on diagnosis, management, or further investigation as appropriate.