Doctor's Assessment Included
Every result includes a professional assessment from a BIG-registered doctor. For treatment decisions, discuss your results with your GP.
Syphilis VDRL test (RPR): what this blood test looks at
The syphilis VDRL (RPR) is a non-treponemal blood test that can reflect disease activity and is also used to follow how the body responds over time. It gives a data point, not a diagnosis. A doctor can interpret it alongside other tests.
What It Measures
This test detects non-treponemal antibodies (reagin) that the body produces in response to cellular damage caused by Treponema pallidum, the bacterium that causes syphilis. The result is reported as a titre, which reflects the level of antibody activity.
A rising titre may indicate active or recent infection, while a declining titre after treatment suggests successful therapy. It is important to note that the RPR test can occasionally produce false positive results due to other conditions, which is why positive results are confirmed with a treponemal-specific test.
Why It Matters
A reactive result can point to syphilis activity, but it does not confirm a diagnosis on its own. Because non-treponemal tests can give false-positive results, a doctor may combine it with a treponemal test. Discuss any result with a huisarts or the BIG-registered doctor.
When to Test
This test can become reactive roughly 1 to 4 weeks after a primary sore (chancre) appears, so testing too early may miss it. A doctor can help you decide on timing and whether a repeat test is useful. Confirmatory testing may be advised after a reactive result.
Recommendations
Male
Non-reactive result indicates no syphilis infection. Continue safe sexual practices.
Reactive result requires confirmation testing and antibiotic treatment. Consult with infectious disease specialist or STD clinic.
Female
Non-reactive result indicates no syphilis infection. Continue safe sexual practices.
Reactive result requires confirmation testing and antibiotic treatment. Consult with infectious disease specialist or STD clinic.
Lifestyle Tips
Consistent condom use reduces the risk of syphilis transmission, although sores can occur in areas not covered by condoms. Regular STI screening is essential, particularly for those at higher risk. Reducing the number of sexual partners also lowers exposure risk.
If diagnosed with syphilis, complete the full course of treatment as prescribed and attend all follow-up appointments for titre monitoring. Notify recent sexual partners so they can be tested and treated. Avoid sexual contact until treatment is complete and your healthcare provider confirms it is safe to resume.