Menopause

The transition toward menopause involves gradual shifts in hormone levels that can span several years. During this time, levels of FSH, LH, and estradiol may change in characteristic patterns. These shifts can be associated with symptoms such as irregular periods, hot flashes, sleep disturbances, or mood changes. Measuring these three hormones together can help clarify whether the changes you experience may be associated with the menopausal transition.

This test may be relevant for:

• Women in their 40s or 50s who are experiencing changes in their menstrual cycle
• Those who have symptoms that could be associated with perimenopause, such as hot flashes or sleep changes
• Anyone whose periods have become irregular and who wants to understand what may be happening hormonally
• Women who want to discuss their hormonal status with a healthcare provider

This panel includes three hormonal markers:

• FSH (Follicle-Stimulating Hormone): tends to rise as ovarian function declines. Elevated FSH is one of the markers commonly associated with the menopausal transition.
• LH (Luteinising Hormone): also produced by the pituitary gland and involved in ovulation. LH levels may change during the transition.
• Estradiol (E2): the primary form of estrogen produced by the ovaries. Declining estradiol levels are associated with many of the symptoms of menopause.

A pattern of elevated FSH with declining estradiol may suggest that the ovaries are producing less estrogen, which is characteristic of the menopausal transition. However, hormone levels can fluctuate significantly during perimenopause, so a single measurement provides a snapshot rather than a definitive assessment.

LH adds context to the picture. Together, these three markers can support a conversation with a healthcare provider about where you may be in the transition and whether any management options might be appropriate.

This test uses a blood sample collected at a certified sample point (afnamepunt). With over 750 partner locations across the Netherlands, you can choose a convenient location. A trained phlebotomist performs the blood draw, and results are typically available within a few working days.

This test may be useful when:

• Your periods have become irregular, less frequent, or have stopped
• You experience symptoms commonly associated with menopause, such as hot flashes, night sweats, or mood changes
• You want hormonal data to discuss with your healthcare provider
• You are unsure whether your symptoms may be related to hormonal changes

Each marker is shown with your value and the reference range. FSH levels that are consistently elevated (typically above 25 to 30 IU/L) in combination with low estradiol may suggest that the menopausal transition is underway. However, during perimenopause, these values can vary from month to month.

A single set of results is informative but may not be conclusive on its own. Your report includes explanations, and a healthcare provider can help interpret the results in the context of your age, symptoms, and menstrual history.

If you are still menstruating, testing on cycle day 2 to 5 is recommended for the most interpretable results (day 1 is the first day of your period). If your periods have stopped or are very irregular, the test can be taken at any time. Note your last menstrual period date for your healthcare provider.

Your results are typically available within a few working days. The report includes your values with reference ranges and clear explanations. If any value falls outside the expected range, this is highlighted. We recommend discussing the results with a healthcare provider, who can assess them in the context of your symptoms and advise on any appropriate next steps.