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STD Serology

Anti-HBc test: what hepatitis B core antibody shows

The anti-HBc test detects hepatitis B core antibodies, which can indicate past or present exposure to the hepatitis B virus. On its own it does not confirm a current infection. A doctor interprets it alongside other markers such as HBsAg and anti-HBs.

Doctor's Assessment Included

Reference Ranges

Expected result Negative

Anti-HBc shows whether you have ever had hepatitis B. Vaccination does not make this result positive — after vaccination anti-HBc is negative and anti-HBs is positive. A positive result does not mean you currently have an infection: it usually reflects an infection that cleared on its own, and in a low-prevalence country such as the Netherlands a positive result is also regularly a false positive. Discuss a positive result with your GP.

Reference ranges may vary between laboratories. When you order a test, a BIG-registered doctor assesses your personal results in context. For treatment decisions, discuss your results with your GP.

Check your own value

What It Measures

This test detects antibodies against the hepatitis B core antigen (HBcAg). These antibodies appear early during infection and can persist for life. The test provides a qualitative result indicating whether anti-HBc antibodies are present, helping to determine exposure history to the hepatitis B virus.

Why It Matters

Anti-HBc is a useful piece of the hepatitis B picture, because it can show exposure even when other markers are unclear. However, it cannot tell you on its own whether an infection is past, resolved, or active. A huisarts or the BIG-registered doctor interprets it together with HBsAg and anti-HBs.

When to Test

Because this marker reflects exposure rather than a precise moment, it is usually tested as part of a wider hepatitis B panel rather than on a strict window. A doctor can advise whether testing now is useful and which other markers to include. A single result should always be interpreted in context.

Recommendations

Male

If Low

Negative result indicates no prior Hepatitis B infection.

If High

Positive result indicates prior or current Hepatitis B infection. Consider further evaluation.

Female

If Low

Negative result indicates no prior Hepatitis B infection.

If High

Positive result indicates prior or current Hepatitis B infection. Consider further evaluation.

Lifestyle Tips

Support liver health by limiting alcohol consumption, maintaining a healthy weight, and eating a balanced diet. If you have not been vaccinated against hepatitis B, consult your healthcare provider about vaccination. Practise safe hygiene and avoid sharing personal items such as razors or toothbrushes.

Frequently Asked Questions

Does a positive anti-HBc mean I have hepatitis B now?
No. Anti-HBc can indicate exposure to hepatitis B, but on its own it does not confirm a current infection. A doctor reads it together with HBsAg and anti-HBs to understand the full picture.
Should this test be done on its own?
It is most informative as part of a wider hepatitis B panel, so a doctor can interpret it alongside other markers. A single marker rarely gives the full answer.
How is the sample taken?
It is a blood test taken at one of the collection locations. You can order online without a referral and discuss the result with a doctor.

Hepatitis B Core Antibody

€51,-