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Hormones

Estrone (E1) Blood Test

Estrone (E1) is a weaker form of estrogen that becomes increasingly important with age. Produced mainly in fat tissue, it reflects your body's estrogen activity after reproductive years. Monitoring E1 may help your healthcare provider assess your overall hormonal health.

Doctor's Assessment Included

Reference Ranges

No established reference range

No reliable reference interval can be established for estrone: the Dutch laboratories that offer the test publish male values that differ by a factor of 1.7, and the published values apply only to LC-MS/MS. Estrone is rarely ordered as a stand-alone test; we would rather show no value than one that is wrong.

Unit: pmol/l

Reference ranges may vary between laboratories. When you order a test, a BIG-registered doctor assesses your personal results in context. For treatment decisions, discuss your results with your GP.

Estrone (E1): what this test measures

This test measures the level of estrone (E1) in your blood. Estrone is produced by fat tissue, the adrenal glands, and the ovaries. After menopause it becomes the primary circulating estrogen. Your healthcare provider may use this result to assess your overall hormonal status.

Estrone (E1): why this value matters

Estrone becomes the primary estrogen as other forms decline with age. Balanced levels may support bone health, metabolic function, and overall wellbeing. Your healthcare provider can help you understand how your estrone levels fit into your broader health picture.

Estrone (E1): when is testing worthwhile?

Your healthcare provider may recommend estrone testing during menopause evaluation, when investigating unexplained weight changes, or as part of a comprehensive hormone panel. Testing could also be suggested for monitoring hormone replacement therapy effectiveness. Consult your provider for personalised guidance.

Estrone (E1): symptoms of a high or low value

Low Levels

Some people may experience accelerated bone loss, increased fatigue, or changes in body composition when estrone levels are low. Joint discomfort and skin changes could also suggest reduced estrogen activity. A healthcare provider can help evaluate whether your levels require attention.

High Levels

Elevated estrone levels may be associated with weight gain, bloating, breast tenderness, or irregular bleeding. High levels could suggest increased conversion from fat tissue or other hormonal imbalances. Your healthcare provider can help determine whether further investigation is appropriate.

Estrone (E1): what to do about an abnormal value

Male

If Low

Low estrone is generally not concerning in men.

If High

Elevated estrone may indicate increased aromatase activity. Consider weight management.

Female

If Low

Low estrone may indicate menopause or ovarian dysfunction.

If High

Elevated estrone may indicate excess body weight or hormone therapy. Discuss with your healthcare provider.

Estrone (E1): lifestyle and this value

Maintaining a healthy body weight may help regulate estrone levels, as fat tissue is a primary production site. Regular exercise, a balanced diet, and limiting alcohol consumption could support healthy estrogen balance. Always consult your healthcare provider before making significant changes.

Estrone (E1): frequently asked questions

What is estrone?
Estrone is a weaker estrogen that becomes dominant after menopause, mainly produced in fat tissue.
Why test estrone specifically?
Estrone testing may help evaluate postmenopausal hormonal status and overall estrogen activity.
Does body weight affect estrone?
Yes, fat tissue produces estrone, so body composition may influence your levels significantly.

Tests with related values

These panels measure values from the same category as this marker.

Whoop

Whoop Women's Health

A 53-biomarker women's health panel inspired by the WHOOP Women's Health Panel — fertility, cycle and thyroid hormones plus a complete metabolic and nutrient base.

Complete Blood Count (CBC) Leukocyte Differential ALP (Alkaline Phosphatase) ALT (Alanine Aminotransferase) AST (Aspartate Aminotransferase) Albumin Total Protein Bilirubin (Total) ApoB (Apolipoprotein B) Total Cholesterol LDL Cholesterol HDL Cholesterol Triglycerides Lipoprotein(a) Urea (BUN) Creatinine eGFR (Estimated Glomerular Filtration Rate) Calcium Bicarbonate Chloride Sodium Potassium Magnesium Cortisol DHEA-S Estradiol (E2) FSH (Follicle Stimulating Hormone) LH (Luteinizing Hormone) SHBG (Sex Hormone Binding Globulin) Total Testosterone Free Testosterone TSH (Thyroid Stimulating Hormone) Glucose (Fasting) HbA1c (Glycated Hemoglobin) Insulin (Fasting) HOMA-IR CRP (C-Reactive Protein) Homocysteine Ferritin Iron (Serum) Transferrin Transferrin Saturation Vitamin D (25-OH) AMH (Anti-Müllerian Hormone) Progesterone Prolactin TPO Antibodies Free T3 (Triiodothyronine) Free T4 (Thyroxine) Leptin Vitamin B12 Folate (Folic Acid) Phosphorus
€709,-
Whoop

Whoop Men's Health

A 48-biomarker men's health panel inspired by the WHOOP Men's Health Panel — testosterone, PSA and prostate health plus a complete metabolic and hormone base.

Complete Blood Count (CBC) Leukocyte Differential ALP (Alkaline Phosphatase) ALT (Alanine Aminotransferase) AST (Aspartate Aminotransferase) Albumin Total Protein Bilirubin (Total) ApoB (Apolipoprotein B) Total Cholesterol LDL Cholesterol HDL Cholesterol Triglycerides Lipoprotein(a) Urea (BUN) Creatinine eGFR (Estimated Glomerular Filtration Rate) Calcium Bicarbonate Chloride Sodium Potassium Magnesium Cortisol DHEA-S Estradiol (E2) FSH (Follicle Stimulating Hormone) LH (Luteinizing Hormone) SHBG (Sex Hormone Binding Globulin) Total Testosterone Free Testosterone TSH (Thyroid Stimulating Hormone) Glucose (Fasting) HbA1c (Glycated Hemoglobin) Insulin (Fasting) HOMA-IR CRP (C-Reactive Protein) Homocysteine Ferritin Iron (Serum) Transferrin Transferrin Saturation Vitamin D (25-OH) PSA (Prostate-Specific Antigen) Prolactin Leptin Uric Acid Zinc
€659,-
Whoop

Whoop Performance Health

A 50-biomarker performance panel inspired by the WHOOP Performance Health Panel — recovery, blood production, thyroid, hormones, iron and nutrient status for people who train.

Complete Blood Count (CBC) Leukocyte Differential ALP (Alkaline Phosphatase) ALT (Alanine Aminotransferase) AST (Aspartate Aminotransferase) Albumin Total Protein Bilirubin (Total) ApoB (Apolipoprotein B) Total Cholesterol LDL Cholesterol HDL Cholesterol Triglycerides Lipoprotein(a) Urea (BUN) Creatinine eGFR (Estimated Glomerular Filtration Rate) Calcium Bicarbonate Chloride Sodium Potassium Magnesium Cortisol DHEA-S Estradiol (E2) FSH (Follicle Stimulating Hormone) LH (Luteinizing Hormone) SHBG (Sex Hormone Binding Globulin) Total Testosterone Free Testosterone TSH (Thyroid Stimulating Hormone) Glucose (Fasting) HbA1c (Glycated Hemoglobin) Insulin (Fasting) HOMA-IR CRP (C-Reactive Protein) Homocysteine Ferritin Iron (Serum) Transferrin Transferrin Saturation Vitamin D (25-OH) IGF-1 (Insulin-like Growth Factor) Creatine Kinase (CK) Reticulocytes Free T3 (Triiodothyronine) Free T4 (Thyroxine) Vitamin B12 Folate (Folic Acid)
€689,-
Whoop

Whoop

A 43-biomarker comprehensive health panel inspired by WHOOP Advanced Labs — a deep look at metabolism, cardiovascular risk, hormones, liver, kidney and inflammation.

SHBG (Sex Hormone Binding Globulin) TSH (Thyroid Stimulating Hormone) ALT (Alanine Aminotransferase) LDL Cholesterol Cortisol DHEA-S Estradiol (E2) Free Testosterone FSH (Follicle Stimulating Hormone) LH (Luteinizing Hormone) Total Testosterone Bicarbonate Calcium Chloride Ferritin Iron (Serum) Magnesium Potassium Sodium Transferrin CRP (C-Reactive Protein) Homocysteine Glucose (Fasting) HbA1c (Glycated Hemoglobin) ApoB (Apolipoprotein B) HDL Cholesterol Total Cholesterol Albumin HOMA-IR ALP (Alkaline Phosphatase) AST (Aspartate Aminotransferase) Bilirubin (Total) Total Protein Urea (BUN) Creatinine Vitamin D (25-OH) eGFR (Estimated Glomerular Filtration Rate) Insulin (Fasting) Leukocyte Differential Transferrin Saturation Lipoprotein(a) Triglycerides Basic Blood Count
€499,-

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Medical standards

Dr. Naimi oversees the medical standards behind our content and assessments.

Medical policy
CIBG Ministerie van Volksgezondheid,
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Estrone (E1)

€39,-