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Coagulation

Protein C Activity

Protein C Activity testing evaluates a critical component of your natural anticoagulant system. Proactive screening identifies deficiency before a thrombotic event occurs.

Doctor's Assessment Included

Protein C (Activity): what this test measures

This test measures the functional anticoagulant activity of Protein C, expressed as a percentage of normal.

Protein C (Activity): why this value matters

Protein C deficiency, whether inherited or acquired, is an important cause of thrombophilia. Early identification allows preventive measures during high-risk situations.

Protein C (Activity): how the blood test works

Referral
No GP referral needed. After the order we arrange the referral through ZorgDomein, within one business day; orders after 17:00 or at the weekend start on the next business day. ZorgDomein emails a barcode, and that barcode is what the draw site needs.
The draw
A blood draw from a vein in the arm, at a partner laboratory's draw site. No home kit, no finger prick.
Which test
on its own €89,-
Where
650+ draw sites run by independent laboratories across the Netherlands. Draw sites

Protein C (Activity): when is testing worthwhile?

Testing could be indicated for unexplained venous thrombosis, family history of Protein C deficiency, or as part of thrombophilia screening. Avoid testing on warfarin as it suppresses Protein C.

Protein C (Activity): symptoms of a high or low value

Low Levels

Low Protein C activity increases thrombosis risk. In adults, symptoms relate to thrombotic events (DVT, PE) rather than the deficiency itself.

High Levels

Elevated Protein C activity is generally not clinically significant and does not require intervention.

Protein C (Activity): lifestyle and this value

If Protein C deficiency is confirmed, reduce thrombosis risk factors, discuss anticoagulation for high-risk situations, and inform family members who may benefit from testing.

Protein C (Activity): frequently asked questions

How common is Protein C deficiency?

Inherited Protein C deficiency affects about 1 in 200-500 people. Most are heterozygous with moderately reduced levels.

Why avoid testing on warfarin?

Warfarin suppresses vitamin K-dependent proteins including Protein C, giving falsely low results.

Is Protein C related to Protein S?

Yes. Protein S is a cofactor for Protein C. Both are vitamin K-dependent natural anticoagulants.

Tests with related values

These panels measure values from the same category as this marker.

Medical reviewer

Medical standards

Dr. Naimi oversees the medical standards behind our content and assessments.

Medical policy
CIBG Ministerie van Volksgezondheid,
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Protein C (Activity)

€89,-