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Vitamins

Methylmalonic Acid (MMA) (Urine)

MMA Urine offers a non-invasive way to assess your functional vitamin B12 status. This convenient test measures how effectively your cells are using B12, potentially detecting deficiency before symptoms develop.

Doctor's Assessment Included

Reference Ranges

No established reference range

There is no established Dutch reference interval for urine methylmalonic acid (creatinine ratio); the standard functional vitamin B12 marker is blood MMA.

Unit: mg/g

Reference ranges may vary between laboratories. When you order a test, a BIG-registered doctor assesses your personal results in context. For treatment decisions, discuss your results with your GP.

What It Measures

This test measures the concentration of methylmalonic acid excreted in urine. When B12 is insufficient, MMA accumulates in the body and is excreted in greater amounts through urine, making this a useful functional indicator of B12 availability.

Why It Matters

Non-invasive monitoring of functional B12 status through urine testing may help you stay informed about your cellular health. Elevated MMA in urine could prompt a conversation with your healthcare provider about B12 optimisation strategies.

When to Test

This test may be considered when B12 deficiency is suspected, as a follow-up to borderline blood B12 results, or when a non-invasive assessment is preferred. It may also be used to monitor B12 treatment effectiveness. Discuss with your healthcare provider.

Symptoms

Low Levels

Low urinary MMA levels generally indicate adequate vitamin B12 function at the cellular level. This is typically considered a normal finding suggesting your body has sufficient B12 for its metabolic needs.

High Levels

Some people with elevated urinary MMA may experience symptoms associated with B12 deficiency, including fatigue, weakness, cognitive difficulties, and neurological symptoms such as tingling in hands and feet. A healthcare provider should evaluate these findings.

Lifestyle Tips

If urinary MMA is elevated, your healthcare provider may recommend increasing B12 intake through diet or supplementation. B12-rich foods include meat, fish, eggs, and dairy products. Regular monitoring can help track improvements over time.

Frequently Asked Questions

How does urine MMA compare to blood MMA testing?
Both tests measure methylmalonic acid as a functional B12 marker. Urine MMA offers a non-invasive alternative to blood testing and can provide similar information about cellular B12 status. Your healthcare provider can advise which test is most appropriate.
Is urine MMA affected by hydration levels?
Hydration can influence urine concentration and potentially affect results. Your healthcare provider may request a first-morning sample or adjust interpretation based on urine concentration markers. Follow the collection instructions carefully.
Can I use urine MMA to monitor my B12 supplementation?
Yes, urinary MMA can be a useful tool for monitoring how well B12 supplementation is working. Decreasing MMA levels over time may indicate that your body is receiving and utilising adequate B12. Discuss monitoring frequency with your healthcare provider.

Tests with related values

These panels measure values from the same category as this marker.

InsideTracker

A 36-biomarker performance and longevity panel inspired by InsideTracker Ultimate — covering heart, hormones, metabolism, inflammation, recovery and iron status.

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€399,-

Methylmalonic Acid (MMA) (Urine)

€98,-