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Hormones

Estrone (E1)

Estrone (E1) is a weaker form of estrogen that becomes increasingly important with age. Produced mainly in fat tissue, it reflects your body's estrogen activity after reproductive years. Monitoring E1 may help your healthcare provider assess your overall hormonal health.

Doctor's Assessment Included

Reference Ranges

No established reference range

No reliable reference interval can be established for estrone: the Dutch laboratories that offer the test publish male values that differ by a factor of 1.7, and the published values apply only to LC-MS/MS. Estrone is rarely ordered as a stand-alone test; we would rather show no value than one that is wrong.

Unit: pmol/l

Reference ranges may vary between laboratories. When you order a test, a BIG-registered doctor assesses your personal results in context. For treatment decisions, discuss your results with your GP.

What It Measures

This test measures the level of estrone (E1) in your blood. Estrone is produced by fat tissue, the adrenal glands, and the ovaries. After menopause it becomes the primary circulating estrogen. Your healthcare provider may use this result to assess your overall hormonal status.

Why It Matters

Estrone becomes the primary estrogen as other forms decline with age. Balanced levels may support bone health, metabolic function, and overall wellbeing. Your healthcare provider can help you understand how your estrone levels fit into your broader health picture.

When to Test

Your healthcare provider may recommend estrone testing during menopause evaluation, when investigating unexplained weight changes, or as part of a comprehensive hormone panel. Testing could also be suggested for monitoring hormone replacement therapy effectiveness. Consult your provider for personalised guidance.

Symptoms

Low Levels

Some people may experience accelerated bone loss, increased fatigue, or changes in body composition when estrone levels are low. Joint discomfort and skin changes could also suggest reduced estrogen activity. A healthcare provider can help evaluate whether your levels require attention.

High Levels

Elevated estrone levels may be associated with weight gain, bloating, breast tenderness, or irregular bleeding. High levels could suggest increased conversion from fat tissue or other hormonal imbalances. Your healthcare provider can help determine whether further investigation is appropriate.

Recommendations

Male

If Low

Low estrone is generally not concerning in men.

If High

Elevated estrone may indicate increased aromatase activity. Consider weight management.

Female

If Low

Low estrone may indicate menopause or ovarian dysfunction.

If High

Elevated estrone may indicate excess body weight or hormone therapy. Discuss with your healthcare provider.

Lifestyle Tips

Maintaining a healthy body weight may help regulate estrone levels, as fat tissue is a primary production site. Regular exercise, a balanced diet, and limiting alcohol consumption could support healthy estrogen balance. Always consult your healthcare provider before making significant changes.

Frequently Asked Questions

What is estrone?
Estrone is a weaker estrogen that becomes dominant after menopause, mainly produced in fat tissue.
Why test estrone specifically?
Estrone testing may help evaluate postmenopausal hormonal status and overall estrogen activity.
Does body weight affect estrone?
Yes, fat tissue produces estrone, so body composition may influence your levels significantly.

Tests with related values

These panels measure values from the same category as this marker.

Whoop

A 44-biomarker comprehensive health panel inspired by WHOOP Advanced Labs — a deep look at metabolism, cardiovascular risk, hormones, liver, kidney and inflammation.

SHBG (Sex Hormone Binding Globulin) TSH (Thyroid Stimulating Hormone) ALT (Alanine Aminotransferase) LDL Cholesterol Cortisol DHEA-S Estradiol (E2) Free Testosterone FSH (Follicle Stimulating Hormone) LH (Luteinizing Hormone) Total Testosterone Bicarbonate Calcium Chloride Ferritin Iron (Serum) Magnesium Potassium Sodium Transferrin CRP (C-Reactive Protein) Homocysteine Glucose (Fasting) HbA1c (Glycated Hemoglobin) ApoB (Apolipoprotein B) HDL Cholesterol Omega-3 Index Total Cholesterol Albumin HOMA-IR ALP (Alkaline Phosphatase) AST (Aspartate Aminotransferase) Bilirubin (Total) Total Protein Urea (BUN) Creatinine Vitamin D (25-OH) eGFR (Estimated Glomerular Filtration Rate) Insulin (Fasting) Leukocyte Differential Transferrin Saturation Lipoprotein(a) Triglycerides Basic Blood Count
€499,-

InsideTracker

A 36-biomarker performance and longevity panel inspired by InsideTracker Ultimate — covering heart, hormones, metabolism, inflammation, recovery and iron status.

SHBG (Sex Hormone Binding Globulin) TSH (Thyroid Stimulating Hormone) ALT (Alanine Aminotransferase) LDL Cholesterol GGT (Gamma-Glutamyl Transferase) Cortisol DHEA-S Estradiol (E2) Free Testosterone Total Testosterone Folate (Folic Acid) Vitamin B12 Calcium Ferritin Iron (Serum) Magnesium Magnesium (Intracellular) Potassium Progesterone Sodium Transferrin CRP (C-Reactive Protein) Glucose (Fasting) HbA1c (Glycated Hemoglobin) ApoB (Apolipoprotein B) HDL Cholesterol Total Cholesterol Albumin AST (Aspartate Aminotransferase) Vitamin D (25-OH) Insulin (Fasting) Leukocyte Differential Creatine Kinase (CK) Transferrin Saturation Triglycerides Basic Blood Count
€399,-

Estrone (E1)

€39,-