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Protoporphyrins

The protoporphyrins test measures levels of heme synthesis precursors in your blood. As part of comprehensive health assessment, this test helps identify potential disruptions in heme production that may be related to iron status, lead exposure, or porphyria.

Doctor's Assessment Included

Reference Ranges

No established reference range

The assay is undetermined (zinc protoporphyrin, total blood protoporphyrin or erythrocyte protoporphyrin IX, in incompatible units) and the linked LOINC code is wrong; no interval can be stated until the assay is confirmed.

Unit: nmol/l

Reference ranges may vary between laboratories. When you order a test, a BIG-registered doctor assesses your personal results in context. For treatment decisions, discuss your results with your GP.

What It Measures

This test measures the level of protoporphyrins in your blood. Protoporphyrins are intermediate compounds in the pathway that produces heme, which is essential for oxygen transport by red blood cells.

Why It Matters

Abnormal protoporphyrin levels can indicate disruptions in heme synthesis, which may be associated with conditions such as iron deficiency, lead exposure, or porphyria. This test can help your healthcare provider investigate the underlying cause.

When to Test

Testing may be recommended when iron deficiency or lead exposure is suspected, when investigating symptoms of porphyria, or as part of occupational health screening. Consult a healthcare professional for interpretation of results.

Symptoms

Low Levels

Low protoporphyrin levels are not typically a cause for concern and generally indicate normal heme synthesis. Consult a healthcare professional for interpretation of results.

High Levels

Elevated protoporphyrin levels may indicate lead poisoning, iron deficiency, or porphyria. Symptoms that can be associated with these conditions include abdominal pain, fatigue, skin sensitivity to light, and neurological changes.

Lifestyle Tips

If elevated protoporphyrins are related to iron deficiency, your healthcare provider may recommend dietary adjustments including iron-rich foods. Minimize exposure to environmental lead sources. Follow up with your healthcare provider for ongoing monitoring.

Frequently Asked Questions

What are protoporphyrins used for in the body?
Protoporphyrins are essential building blocks for heme, the iron-containing component of hemoglobin that carries oxygen in your blood. They are a normal part of the heme production pathway.
Can iron deficiency cause elevated protoporphyrins?
Yes, when iron is insufficient, protoporphyrins can accumulate because they cannot be combined with iron to form heme. This is why elevated protoporphyrins can be an indicator of iron deficiency.
Is this test related to lead exposure screening?
Yes, lead interferes with heme synthesis, causing protoporphyrins to accumulate. Elevated levels, particularly zinc protoporphyrins, can be associated with lead exposure and may be used as a screening tool.

Tests with related values

These panels measure values from the same category as this marker.

Whoop

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SHBG (Sex Hormone Binding Globulin) TSH (Thyroid Stimulating Hormone) ALT (Alanine Aminotransferase) LDL Cholesterol Cortisol DHEA-S Estradiol (E2) Free Testosterone FSH (Follicle Stimulating Hormone) LH (Luteinizing Hormone) Total Testosterone Bicarbonate Calcium Chloride Ferritin Iron (Serum) Magnesium Potassium Sodium Transferrin CRP (C-Reactive Protein) Homocysteine Glucose (Fasting) HbA1c (Glycated Hemoglobin) ApoB (Apolipoprotein B) HDL Cholesterol Omega-3 Index Total Cholesterol Albumin HOMA-IR ALP (Alkaline Phosphatase) AST (Aspartate Aminotransferase) Bilirubin (Total) Total Protein Urea (BUN) Creatinine Vitamin D (25-OH) eGFR (Estimated Glomerular Filtration Rate) Insulin (Fasting) Leukocyte Differential Transferrin Saturation Lipoprotein(a) Triglycerides Basic Blood Count
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SHBG (Sex Hormone Binding Globulin) TSH (Thyroid Stimulating Hormone) ALT (Alanine Aminotransferase) LDL Cholesterol GGT (Gamma-Glutamyl Transferase) Cortisol DHEA-S Estradiol (E2) Free Testosterone Total Testosterone Folate (Folic Acid) Vitamin B12 Calcium Ferritin Iron (Serum) Magnesium Magnesium (Intracellular) Potassium Progesterone Sodium Transferrin CRP (C-Reactive Protein) Glucose (Fasting) HbA1c (Glycated Hemoglobin) ApoB (Apolipoprotein B) HDL Cholesterol Total Cholesterol Albumin AST (Aspartate Aminotransferase) Vitamin D (25-OH) Insulin (Fasting) Leukocyte Differential Creatine Kinase (CK) Transferrin Saturation Triglycerides Basic Blood Count
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Protoporphyrins

€68,-