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Hematology

Indirect Coombs test: screening for irregular antibodies

The indirect Coombs test screens for unexpected antibodies in your blood that may react against red blood cells. It is an important test for transfusion safety and prenatal care.

Doctor's Assessment Included

Reference Ranges

Expected result Negative

Reference ranges may vary between laboratories. When you order a test, a BIG-registered doctor assesses your personal results in context. For treatment decisions, discuss your results with your GP.

Check your own value

What It Measures

This test detects irregular antibodies circulating in your blood serum that could bind to foreign red blood cells. These antibodies may develop after previous transfusions, pregnancies, or certain immune responses.

Why It Matters

Detecting irregular antibodies before a transfusion helps prevent potentially serious transfusion reactions. During pregnancy, the test can identify antibodies that may cross the placenta and affect the baby's red blood cells, allowing timely medical intervention.

When to Test

This test is typically performed before blood transfusions, during pregnancy (especially for Rh-negative women), and as part of pre-operative screening. Consult a healthcare professional for interpretation of results.

Lifestyle Tips

Inform healthcare providers of any previous transfusion reactions or known antibodies. Keep your medical records accessible, especially if you have been identified as having irregular antibodies. During pregnancy, attend all scheduled prenatal appointments for timely screening.

Frequently Asked Questions

What does a positive indirect Coombs test mean?
A positive result means irregular antibodies were detected in your blood. This does not necessarily indicate illness, but it is important information for ensuring safe blood transfusions and managing pregnancy. Your healthcare provider will explain the implications for your specific situation.
How is this test different from the direct Coombs test?
The indirect Coombs test detects antibodies floating freely in the blood serum, while the direct Coombs test looks for antibodies already attached to red blood cells. Each test serves a different clinical purpose.

Tests with related values

These panels measure values from the same category as this marker.

InsideTracker

A 36-biomarker performance and longevity panel inspired by InsideTracker Ultimate — covering heart, hormones, metabolism, inflammation, recovery and iron status.

SHBG (Sex Hormone Binding Globulin) TSH (Thyroid Stimulating Hormone) ALT (Alanine Aminotransferase) LDL Cholesterol GGT (Gamma-Glutamyl Transferase) Cortisol DHEA-S Estradiol (E2) Free Testosterone Total Testosterone Folate (Folic Acid) Vitamin B12 Calcium Ferritin Iron (Serum) Magnesium Magnesium (Intracellular) Potassium Progesterone Sodium Transferrin CRP (C-Reactive Protein) Glucose (Fasting) HbA1c (Glycated Hemoglobin) ApoB (Apolipoprotein B) HDL Cholesterol Total Cholesterol Albumin AST (Aspartate Aminotransferase) Vitamin D (25-OH) Insulin (Fasting) Leukocyte Differential Creatine Kinase (CK) Transferrin Saturation Triglycerides Basic Blood Count
€399,-

Whoop

A 44-biomarker comprehensive health panel inspired by WHOOP Advanced Labs — a deep look at metabolism, cardiovascular risk, hormones, liver, kidney and inflammation.

SHBG (Sex Hormone Binding Globulin) TSH (Thyroid Stimulating Hormone) ALT (Alanine Aminotransferase) LDL Cholesterol Cortisol DHEA-S Estradiol (E2) Free Testosterone FSH (Follicle Stimulating Hormone) LH (Luteinizing Hormone) Total Testosterone Bicarbonate Calcium Chloride Ferritin Iron (Serum) Magnesium Potassium Sodium Transferrin CRP (C-Reactive Protein) Homocysteine Glucose (Fasting) HbA1c (Glycated Hemoglobin) ApoB (Apolipoprotein B) HDL Cholesterol Omega-3 Index Total Cholesterol Albumin HOMA-IR ALP (Alkaline Phosphatase) AST (Aspartate Aminotransferase) Bilirubin (Total) Total Protein Urea (BUN) Creatinine Vitamin D (25-OH) eGFR (Estimated Glomerular Filtration Rate) Insulin (Fasting) Leukocyte Differential Transferrin Saturation Lipoprotein(a) Triglycerides Basic Blood Count
€499,-

Coombs Test (Indirect)

€33,-