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Allergy & Intolerance

Zonulin Test

Zonulin assesses intestinal barrier function as part of comprehensive gut health evaluation. Early identification of increased permeability enables targeted interventions.

Doctor's Assessment Included

Zonulin: what this test measures

This test measures zonulin concentration in blood or stool. Zonulin is the only known physiological regulator of intestinal tight junction permeability. Higher levels suggest greater permeability.

Zonulin: why this value matters

Increased intestinal permeability may allow harmful substances to cross the gut barrier, triggering immune responses. Elevated zonulin has been linked to coeliac disease, type 1 diabetes, and inflammatory bowel disease.

Zonulin: when is testing worthwhile?

Consider testing if you have chronic digestive symptoms, autoimmune conditions, food sensitivities, or as part of a functional gut health assessment. Consult your healthcare provider.

Zonulin: symptoms of a high or low value

Low Levels

Low zonulin suggests normal intestinal barrier function and healthy tight junction regulation.

High Levels

Elevated zonulin may be associated with bloating, gas, diarrhoea, food sensitivities, fatigue, and joint pain. It may be present in autoimmune conditions and chronic inflammation.

Zonulin: lifestyle and this value

Support gut barrier health with a diverse, fibre-rich diet, limiting ultra-processed foods, managing stress, adequate sleep, and avoiding unnecessary NSAID use. Probiotics may support barrier function under medical guidance.

Zonulin: frequently asked questions

What is leaky gut?
Leaky gut refers to increased intestinal permeability where tight junctions become less effective. Zonulin regulates these junctions.
Is zonulin testing widely accepted?
Zonulin research is growing but still evolving. Some aspects of methodology are being refined. Discuss relevance with your healthcare provider.
Can diet affect zonulin?
Yes. Gluten increases zonulin in susceptible individuals. Reducing gluten and processed food may help normalise levels.

Tests with related values

These panels measure values from the same category as this marker.

Whoop

Whoop Metabolic Health

A 51-biomarker metabolic panel inspired by the WHOOP Metabolic Health Panel — blood sugar regulation, insulin, thyroid, liver and the mineral cofactors behind your metabolism.

Complete Blood Count (CBC) Leukocyte Differential ALP (Alkaline Phosphatase) ALT (Alanine Aminotransferase) AST (Aspartate Aminotransferase) Albumin Total Protein Bilirubin (Total) ApoB (Apolipoprotein B) Total Cholesterol LDL Cholesterol HDL Cholesterol Triglycerides Lipoprotein(a) Urea (BUN) Creatinine eGFR (Estimated Glomerular Filtration Rate) Calcium Bicarbonate Chloride Sodium Potassium Magnesium Cortisol DHEA-S Estradiol (E2) FSH (Follicle Stimulating Hormone) LH (Luteinizing Hormone) SHBG (Sex Hormone Binding Globulin) Total Testosterone Free Testosterone TSH (Thyroid Stimulating Hormone) Glucose (Fasting) HbA1c (Glycated Hemoglobin) Insulin (Fasting) HOMA-IR CRP (C-Reactive Protein) Homocysteine Ferritin Iron (Serum) Transferrin Transferrin Saturation Vitamin D (25-OH) Leptin Zinc Selenium Iodine Copper Free T3 (Triiodothyronine) Free T4 (Thyroxine) GGT (Gamma-Glutamyl Transferase)
€799,-
Whoop

Whoop Women's Health

A 53-biomarker women's health panel inspired by the WHOOP Women's Health Panel — fertility, cycle and thyroid hormones plus a complete metabolic and nutrient base.

Complete Blood Count (CBC) Leukocyte Differential ALP (Alkaline Phosphatase) ALT (Alanine Aminotransferase) AST (Aspartate Aminotransferase) Albumin Total Protein Bilirubin (Total) ApoB (Apolipoprotein B) Total Cholesterol LDL Cholesterol HDL Cholesterol Triglycerides Lipoprotein(a) Urea (BUN) Creatinine eGFR (Estimated Glomerular Filtration Rate) Calcium Bicarbonate Chloride Sodium Potassium Magnesium Cortisol DHEA-S Estradiol (E2) FSH (Follicle Stimulating Hormone) LH (Luteinizing Hormone) SHBG (Sex Hormone Binding Globulin) Total Testosterone Free Testosterone TSH (Thyroid Stimulating Hormone) Glucose (Fasting) HbA1c (Glycated Hemoglobin) Insulin (Fasting) HOMA-IR CRP (C-Reactive Protein) Homocysteine Ferritin Iron (Serum) Transferrin Transferrin Saturation Vitamin D (25-OH) AMH (Anti-Müllerian Hormone) Progesterone Prolactin TPO Antibodies Free T3 (Triiodothyronine) Free T4 (Thyroxine) Leptin Vitamin B12 Folate (Folic Acid) Phosphorus
€709,-
Whoop

Whoop Men's Health

A 48-biomarker men's health panel inspired by the WHOOP Men's Health Panel — testosterone, PSA and prostate health plus a complete metabolic and hormone base.

Complete Blood Count (CBC) Leukocyte Differential ALP (Alkaline Phosphatase) ALT (Alanine Aminotransferase) AST (Aspartate Aminotransferase) Albumin Total Protein Bilirubin (Total) ApoB (Apolipoprotein B) Total Cholesterol LDL Cholesterol HDL Cholesterol Triglycerides Lipoprotein(a) Urea (BUN) Creatinine eGFR (Estimated Glomerular Filtration Rate) Calcium Bicarbonate Chloride Sodium Potassium Magnesium Cortisol DHEA-S Estradiol (E2) FSH (Follicle Stimulating Hormone) LH (Luteinizing Hormone) SHBG (Sex Hormone Binding Globulin) Total Testosterone Free Testosterone TSH (Thyroid Stimulating Hormone) Glucose (Fasting) HbA1c (Glycated Hemoglobin) Insulin (Fasting) HOMA-IR CRP (C-Reactive Protein) Homocysteine Ferritin Iron (Serum) Transferrin Transferrin Saturation Vitamin D (25-OH) PSA (Prostate-Specific Antigen) Prolactin Leptin Uric Acid Zinc
€659,-

Medical reviewer

Medical standards

Dr. Naimi oversees the medical standards behind our content and assessments.

Medical policy
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Zonulin

€98,-