Home
/
Markers
/
Kidney
/
Cystatin C

Cystatin C Test

Cystatin C is an advanced kidney function marker that provides a highly accurate estimate of filtration rate. When combined with creatinine testing, it offers the most comprehensive assessment of kidney health available.

Doctor's Assessment Included

Cystatin C: what this test measures

This test measures the concentration of cystatin C in your blood. Cystatin C is produced at a nearly constant rate by all cells that contain a nucleus, making it a reliable indicator of kidney filtration.

Unlike creatinine, cystatin C production is not significantly affected by muscle mass, gender, or diet. This makes it particularly useful in situations where creatinine may be unreliable, such as in individuals with unusual muscle mass or dietary patterns.

Cystatin C: why this value matters

Cystatin C provides an independent estimate of kidney function that complements traditional creatinine-based measurements. When used together, cystatin C and creatinine offer a more accurate assessment of glomerular filtration rate than either marker alone.

This marker is especially valuable for detecting early kidney dysfunction, as cystatin C levels may rise before creatinine in the early stages of kidney disease. It can help identify kidney problems that might be missed by creatinine testing alone.

Cystatin C: when is testing worthwhile?

Cystatin C testing may be recommended when a more precise assessment of kidney function is needed, or when creatinine results may be unreliable due to factors such as extreme muscle mass, vegetarian diets, or limb amputation.

It is also valuable for early detection of kidney disease in high-risk populations, including individuals with diabetes, cardiovascular disease, or a family history of kidney problems.

Cystatin C: symptoms of a high or low value

Low Levels

Low cystatin C levels are generally not clinically significant
May occasionally be seen with certain medications
Typically does not require further investigation

High Levels

Fatigue and reduced energy levels
Swelling in the legs, ankles, or around the eyes
Changes in urination patterns
Shortness of breath
Difficulty concentrating

Cystatin C: what to do about an abnormal value

Male

If Low

Low cystatin C indicates good kidney function. No action needed.

If High

Elevated cystatin C may indicate kidney dysfunction. Consult a nephrologist for further evaluation.

Female

If Low

Low cystatin C indicates good kidney function. No action needed.

If High

Elevated cystatin C may indicate kidney dysfunction. Consult a nephrologist for further evaluation.

Cystatin C: lifestyle and this value

Support kidney health by staying well hydrated and maintaining a balanced diet. Manage blood pressure and blood sugar levels proactively, as cardiovascular and metabolic conditions are major contributors to kidney decline.

Avoid prolonged use of medications that can affect the kidneys without medical supervision. Maintain a healthy weight and engage in regular physical activity, as both support overall cardiovascular and renal health.

Cystatin C: frequently asked questions

Why is cystatin C tested instead of creatinine?

Cystatin C is less affected by muscle mass, diet, and age than creatinine, making it a more reliable indicator of kidney function in certain populations. It is often used alongside creatinine for a more accurate assessment, particularly when creatinine results may be misleading.

Can cystatin C detect kidney problems earlier than creatinine?

Yes, research suggests that cystatin C may detect early kidney dysfunction before creatinine levels begin to rise. This makes it a valuable tool for early intervention in individuals at risk of kidney disease.

Is cystatin C affected by exercise or diet?

Unlike creatinine, cystatin C is not significantly affected by muscle mass, exercise intensity, or dietary protein intake. This is one of its key advantages as a kidney function marker, particularly for active individuals or individuals with unusual body composition.

Test Products

This marker is included in the following test panels.

Whoop

Whoop Heart Health

A 45-biomarker heart health panel inspired by the WHOOP Heart Health Panel — an advanced look at cholesterol, lipoproteins, inflammation and kidney function.

Complete Blood Count (CBC) Leukocyte Differential ALP (Alkaline Phosphatase) ALT (Alanine Aminotransferase) AST (Aspartate Aminotransferase) Albumin Total Protein Bilirubin (Total) ApoB (Apolipoprotein B) Total Cholesterol LDL Cholesterol HDL Cholesterol Triglycerides Lipoprotein(a) Urea (BUN) Creatinine eGFR (Estimated Glomerular Filtration Rate) Calcium Bicarbonate Chloride Sodium Potassium Magnesium Cortisol DHEA-S Estradiol (E2) FSH (Follicle Stimulating Hormone) LH (Luteinizing Hormone) SHBG (Sex Hormone Binding Globulin) Total Testosterone Free Testosterone TSH (Thyroid Stimulating Hormone) Glucose (Fasting) HbA1c (Glycated Hemoglobin) Insulin (Fasting) HOMA-IR CRP (C-Reactive Protein) Homocysteine Ferritin Iron (Serum) Transferrin Transferrin Saturation Vitamin D (25-OH) Cystatin C Uric Acid

€629,-

Medical reviewer

Medical standards

Dr. Naimi oversees the medical standards behind our content and assessments.

Medical policy

CIBG Ministerie van Volksgezondheid,
Welzijn en Sport Official BIG registration BIG 49928676701